San Salvador Island is the first stage in Otomedius. It's like a resort in the open sea. The boss in this stage is Eliza's pet, a purple seal.
- When Eliza appears, Neil, the fish on the ship above her head, is replaced by a black and white photograph of him with a black ribbon above, signifying death.
- The penguins from Parodius are back, but this is the only stage where penguins are enemies you fight directly. With the exception of some penguins piloting various mechs in the next stages, the penguins are merely in the background.