Effective commander of Angel Squadron, Operetta is a holographic robot girl who coordinates the squadron's activities and dispatches them on their missions.
- Player re-appears
- R.V. システム, リスタート! (R.V. Shistemu, Ristaato) (R.V. System, Restart!)
- Game Over
- ゲームオーバー (Geemu Oobaa) (Game Over)
- Operetta fulfills the narrator's duties from previous Gradius titles. Ex: "Homing Missile!"', "Aqua Laser Lvl 2!"
- Her catchphrase, well you know it "Destroy the core!"
- She may be a hologram, or perhaps she doesn't really exist. She could also be a very intelligent humanoid robot.
- In Otomedius Excellent, her swimsuit artwork can be obtained by beating the game on Expert with a Chibi Hyper Anoa.