Doom is a three-headed humanoid and is a rarity among the series because unlike most final bosses in Gradius; Doom actually fights back. He seems to have somehow revived the Zelos Force and a Salamander for his invasion, as seen in the game's intro.
Doom fires many purple bullets at the player and can also form and fire green energy balls. When he starts getting close to being destroyed, he makes objects fall from the top of the screen. His bullet patterns also become harder and harder to dodge as he loses health.The bullet patterns that Doom uses are comparable to those of Bullet Hell bosses.
- Due to the soundtrack calling the final boss theme "Giga's Rage",
|Ships||Vic Viper • Lord British • Sabel Tiger (Iggy Rock) • Thrasher (Zowie Scott) • Super Cobra • Galaxy • Purple Emperor • Red Devil|
|Salamander stages||Bionic Germ • Meteorite Space • Burning Chaos • Volcano Area • Salamander Planetoid|
|Salamander (MSX) stages||Top Flight Speed to Latis • Conduct to Space Station Zot • Set the Crush Blow System - Planet Eioneus • Set the Crush Blow System - Planet Lavinia • Set the Crush Blow System - Planet Kierke • Wrath of Venom • Crush Salamander|
|Life Force-only stages||Organic Speed Zone • Temple Zone|
|Salamander 2 stages||Sub-life Space • Prominence Fortress • Bio Hazard • Huge Battleship • Asteroid • Doom Fortress|
|Salamander bosses||Brain Golem • Tetran • Intruder • Fortress Valis • Death • Big Core X3 • Jumping Moai • Zelos Force|
|Port exclusive bosses||Zylom • Gaw • Giga • Tutankhamon • Dead End • Enigma • True Venom • Metal Slave • Zelos Barrier|
|Salamander 2 bosses||Biter • Hydra • Abadon • Tenny Rop • Plate Core • Cerberus • Doom|
|End Bosses & Major Enemies|
|Major Recurring Foes||Gofer • Bacterion • Dr Venom • Zelos Force (Zeros) • Lars Empire|
|Minor Enemies||Xaerous Brain • O.V.U.M. • Eleos Brain • Mother Computer Z • Guardian Core • Central Server • Genocide Core • Metal Slave • Zelos Barrier • Doom|